Studies have shown a possible effect on human papillomavirus (HPV)-related precancerous lesions in cervical cytology. A prospective controlled pilot study, in which 54 women with an HPV+low-grade squamous intraepithelial lesion diagnosis in their PAP smear were followed for 6 months. The intervention group consumed a daily probiotic drink during the study period; the control group received no treatment, according to common care policy. Outcome measures were the control PAP smear and HPV status after 6 months. Probiotic users had a twice as high chance of clearance of cytological abnormalities (60 vs. 31%, P=0.05). HPV was cleared in 19% of control patients versus 29% of probiotic users (P=0.41). This exploratory pilot study suggests that the probiotic studied promotes the clearance of HPV-related cytological abnormalities. If confirmed, this would represent an entirely new option to manage cervical cancer precursors.
A growing interest has developed in microbiota and in the concept of maintaining a special balance between Lactobacillusand other bacteria species in order to promote women’s well-being. The aim of the study was to confirm that vaginal Lactobacillilong-lasting implementation in women with HPV-infections and concomitant bacterial vaginosis or vaginitis might be able to help in solving the viral infection, by re-establishing the original eubiosis
A total of 117 women affected by bacterial vaginosis or vaginitis with concomitant HPV-infections were enrolled at Department of Gynecological Obstetrics and Urological Sciences, La Sapienza University Italy. Probiotic's were found to help in restore normal floral
Conclusion Probiotics are a complementary and integrative therapy useful in the treatment and prevention of urogenital infections in women.